Cytochrome P450 Inhibitors

CYP1

CYP2

CYP3

CYP4

CYP11

CYP17

Aromatase/CYP19A1

CYP26

CYP51

CYP1A2

CYP2D6

CYP2C9

CYP2C19

CYP3A4

CYP17A1

Cytochrome P450 Degraders, Inducers, Inhibitors, Activators & Modulators

Product Name	CYP1	CYP2	CYP3	CYP4	CYP11	CYP17	Aromatase/CYP19A1	CYP26	CYP51	CYP1A2	CYP2D6	CYP2C9	CYP2C19	CYP3A4	CYP17A1	Purity
Verapamil			CYP3													99.96%
Apigenin		CYP2														99.22%
Fenofibrate		CYP2C19, IC₅₀: 0.2 μM CYP2B6, IC₅₀: 0.7 μM CYP2C9, IC₅₀: 9.7 μM CYP2C8, IC₅₀: 4.8 μM	CYP3A4, IC₅₀: 142.1 μM													99.97%
Letrozole							Aromatase									99.95%
Clopidogrel-β-D-glucuronide		CYP2C8
Verapamil hydrochloride			CYP3													99.98%
Ketoconazole			CYP3	CYP4												99.51%
Abiraterone						CYP17										99.88%
1-Aminobenzotriazole		CYP2	CYP3													99.88%
Stiripentol		CYP2	CYP3													99.99%
Abiraterone acetate						CYP17										99.96%
Clarithromycin			CYP3													99.90%
Cepharanthine		CYP2E1, IC₅₀: 25.62 μM CYP2C9, IC₅₀: 24.57 μM	CYP3A4, IC₅₀: 16.29 μM													99.87%
Gemfibrozil 1-O-β-glucuronide		CYP2C8, IC₅₀: 4.07 μM														99.87%
Oleuropein							Aromatase									99.05%
Diosmetin	CYP1															99.63%
Salvianolic acid C		CYP2C8, Ki: 4.82 μM CYP2J2, Ki: 5.75 μM														99.94%
Fomepizole		CYP2E1														99.78%
Talarozole								CYP26								99.61%
HET0016				CYP4												99.69%
Galangin	CYP1															99.96%
(S)-Mephenytoin		CYP2														99.85%
Sulfaphenazole		CYP2C9														99.85%
Anastrozole							Aromatase									99.99%
Exemestane							Aromatase									99.83%
Cobicistat			CYP3													99.77%
Gemfibrozil	CYP1A2, Ki: 82 μM	CYP2C9, Ki: 5.8 μM CYP2C19, Ki: 24 μM CYP2C8, Ki: 69 μM														99.91%
Clobetasol propionate			CYP3A5, IC₅₀: 0.206 μM CYP3A4, IC₅₀: 15.6 μM													99.72%
Troleandomycin			CYP3													98.58%
Schisandrin A			CYP3A, IC₅₀: 6.6 μM													99.89%
Isavuconazole			CYP3													99.99%
Clopidogrel hydrogen sulfate		CYP2B6, IC₅₀: 18.2 nM CYP2C19, IC₅₀: 524 nM														99.88%
Bergamottin	CYP1A1, Ki: 10.703 nM CYP1A1, IC₅₀: 0.192 μM CYP1A2, IC₅₀: 5.077 μM	CYP2B2, IC₅₀: 4.535 μM CYP2B1, IC₅₀: 9.495 μM														99.97%
TMS	CYP1B1, IC₅₀: 6 nM CYP1A1, IC₅₀: 300 nM CYP1A2, IC₅₀: 3.1 μM CYP1B1, Ki: 3 nM															99.40%
Ginsenoside C-K		CYP2C9, IC₅₀: 32 μM CYP2A6, IC₅₀: 63.6 μM														99.92%
Gentiopicroside		CYP2														99.83%
K777			CYP3													99.77%
AS1810722			CYP3A4													98.10%
Alpha-Naphthoflavone							Aromatase									99.76%
Olivetol		CYP2														99.81%
Atazanavir			CYP3													99.86%
Ginsenoside Rd	CYP1A2, IC₅₀: 78.4 μM	CYP2D6, IC₅₀: 58 μM CYP2C9, IC₅₀: 85.1 μM	CYP3A4, IC₅₀: 81.7 μM													99.88%
Phillyrin	CYP1	CYP2														98.99%
7-Ethoxyresorufin	CYP1															99.61%
Pregnenolone 16α-carbonitrile		CYP2	CYP3													98.48%
Tetrahydrocurcumin		CYP2C9	CYP3A4													98.96%
Curcumenol			CYP3													99.98%
Dronedarone			CYP3													99.93%
Rhapontigenin	CYP1A1, IC₅₀: 400 nM															99.66%
Chlorzoxazone		CYP2														99.77%
Tebuconazole									CYP51							99.63%
Endoxifen							Aromatase									99.42%
Schisandrol B		CYP2	CYP3A													99.99%
Bergaptol			CYP3													99.44%
Clomethiazole		CYP2														98.65%
Atazanavir sulfate			CYP3													99.87%
Ticlopidine		CYP2	CYP3													99.56%
Galeterone						CYP17										99.87%
5,7-Dimethoxyflavone			CYP3A													99.86%
Mephenytoin		CYP2														99.96%
Dihydrokavain												CYP2C9, IC₅₀: 130.95 μM	CYP2C19, IC₅₀: 10.05 μM	CYP3A4, IC₅₀: 78.59 μM		99.94%
(S)-(+)-N-3-Benzylnirvanol													CYP2C19, Ki: 250 nM			99.82%
CYP3cide			CYP3A4, EC₅₀: 30 nM CYP3A5, EC₅₀: 17 μM CYP3A7, EC₅₀: 71 μM													99.92%
Oteseconazole												CYP2C9, IC₅₀: 99 μM	CYP2C19, IC₅₀: 72 μM			99.46%
Fadrozole hydrochloride							Aromatase									99.91%
Endoxifen hydrochloride							Aromatase									98.04%
Fipronil	CYP1	CYP2	CYP3													99.01%
BMS-986202		CYP2C19, IC₅₀: 14 μM														99.92%
AZD7325	CYP1A2		CYP3A4													99.71%
Cecropin B			CYP3													99.00%
Fadrozole							Aromatase									99.78%
LKY-047		CYP2J2, IC₅₀: 1.7 μM														99.94%
Obtusifoliol									CYP51							99.86%
APD668		CYP2C9, Ki: 0.1 μM														99.73%
Cedrol		CYP2	CYP3													99.76%
Isosilybin			CYP3													99.95%
Columbamine chloride														CYP3A4, IC₅₀: 30.6 μM		98.63%
Utreloxastat										CYP1A2, IC₅₀: > 5.3 μM						99.69%
Oxiconazole nitrate			CYP3A4 CYP3													≥98.0%
Casopitant mesylate			CYP3A4													99.83%
Cephaeline dihydrochloride		CYP2														99.84%
6',7'-Dihydroxybergamottin			CYP3A4													≥99.0%
β-Apo-8'-carotenal	CYP1A1 CYP1A2
Ginsenoside F1		CYP2	CYP3A4 CYP3													≥99.0%
Rehmannioside A		CYP2C9, IC₅₀: 12.62 μM CYP2D6, IC₅₀: 16.43 μM	CYP3A4, IC₅₀: 10.08 μM													99.96%
Liarozole								CYP26, IC₅₀: 7 μM								98.83%
Flavanone							Aromatase									99.73%
Friedelin		CYP2	CYP3													≥99.0%
Harmalol hydrochloride	CYP1															99.72%
Seviteronel						CYP17										99.83%
Nicotelline								CYP26, Ki: ≥300 μM								99.92%
MS-PPOH		CYP2														99.27%
Aminoglutethimide							Aromatase									98.79%
Clitorin							Aromatase, IC₅₀: 77.41 nM									99.45%
Ezutromid	CYP1															98.87%
PC945									CYP51A, IC₅₀: 0.23 μM CYP51B, IC₅₀: 0.22 μM							99.27%
Oxolamine citrate		CYP2B1 CYP2B2														99.87%
TP0472993				CYP4A11, IC₅₀: 140 nM CYP4F2, IC₅₀: 40 nM												98.22%
Tetrahydropiperine	CYP1A1, IC₅₀: 23 μM															99.41%
Dihydrolanosterol									CYP51							99.56%
Sulcatone	CYP1B1															99.80%
Quilseconazole									CYP51							98.98%
Orteronel						CYP17										99.70%
AMG-208			CYP3A4, IC₅₀: 32 μM													99.86%
NN1177 TFA														CYP3A4		98.66%
Sudan IV	CYP1A1															≥98.0%
(R)-(+)-Aminoglutethimide							Aromatase
Columbamine														CYP3A4, IC₅₀: 30.6 μM		99.95%
D4-abiraterone						CYP17										99.75%
Linderane		CYP2														99.61%
20-HETE inhibitor-2				CYP4F2 CYP4A11												98.12%
2-Phenyl-2-(1-piperidinyl)propane	CYP1A2, IC₅₀: >300 μM	CYP2B6, IC₅₀: 5.1 μM CYP2B6, Ki: 5.6 μM CYP2D6, IC₅₀: 74 μM CYP2A6, IC₅₀: >300 μM CYP2C8, IC₅₀: >300 μM CYP2C9, EC₅₀: >300 μM CYP2C19, IC₅₀: >300 μM CYP2E1, IC₅₀: >300 μM	CYP3A, IC₅₀: 200 μM													99.72%
Carbosulfan	CYP1	CYP2	CYP3													≥98.0%
DMU2105	CYP1B1, IC₅₀: 10 nM CYP1A1, IC₅₀: 742 nM															99.54%
Fomepizole hydrochloride		CYP2E1														99.85%
Mefentrifluconazole									CYP51A, Kd: 0.5 nM							99.61%
Chlorzoxazone (Standard)		CYP2														99.81%
Chrysosplenetin			CYP3A CYP3													99.68%
Dapaconazole								CYP26, IC₅₀: 1.4 μM								99.76%
Liarozole dihydrochloride								CYP26, IC₅₀: 7 μM								99.04%
N-Nornuciferine		CYP2														99.94%
IDO1-IN-19		CYP2C9, IC₅₀: 8.64 μM														98.52%
CYP1B1-IN-4	CYP1B1, IC₅₀: 0.2 nM CYP1A1, IC₅₀: 3.98 μM															99.09%
Azamulin			CYP3A, IC₅₀: 0.03-0.24 μM
Fenofibrate (Standard)		CYP2B6 CYP2C19 CYP2C8 CYP2C9	CYP3A4													99.91%
ACP-5862		CYP2C8	CYP3A4													98.41%
DMU2139	CYP1B1, IC₅₀: 9 nM CYP1A1, IC₅₀: 795 nM															≥98.0%
Nampt-IN-5			CYP3, IC₅₀: 0.7 nM													98.02%
Melperone											CYP2D6					99.84%
α-Terpinyl acetate		CYP2B6, Kd: 5.4  μM
Phortress	CYP1															99.25%
CYP19A1-IN-2							Aromatase									98.88%
ML252	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM													99.9%
2,6-Dimethylquinoline	CYP1A2, IC₅₀: 3.3 μM	CYP2B6, IC₅₀: 480 μM														99.95%
ONT-993		CYP2D6, IC₅₀: 7.9 μM														99.85%
BI 653048	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM													99.84%
Exemestane (Standard)							Aromatase									99.63%
Apigenin (Standard)		CYP2
SDZ285428									CYP51							98.00%
Pradefovir mesylate			CYP3													99.89%
Antihistamine-1		CYP2D6, IC₅₀: 5.4 μM														99.45%
CYP4A11/CYP4F2-IN-1				CYP4A11, IC₅₀: 19 nM CYP4F2, IC₅₀: 17 nM												99.82%
YM511							Aromatase									99.73%
1'-Hydroxy bufuralol		CYP2
Clarithromycin (Standard)			CYP3
Abiraterone acetate (Standard)						CYP17										99.85%
SR9186			CYP3													98.06%
Dagrocorat hydrochloride		CYP2D6	CYP3A													99.85%
RG-12525			CYP3A4, Ki: 0.5 μM													98.31%
hCYP3A4 Fluorogenic substrate 1			CYP3A4, Km: 0.36 μM													99.27%
Seviteronel (R enantiomer)						CYP17										98.82%
CYP1B1 ligand 3	CYP1B1, IC₅₀: 11.9 nM CYP1A1, IC₅₀: 278.7 nM CYP1A2, IC₅₀: 3913.5 nM
Letrozole-d₄							Aromatase									99.82%
Abiraterone decanoate						CYP17										99.69%
17-HETE	CYP1B1															98.2%
Pyributicarb			CYP3													99.94%
BMS-819881			CYP3A4, EC₅₀: 13 μM													99.78%
ε-Viniferin	CYP1A2, Ki: 5 μM ((EROD))	CYP2B6, Ki: 3 μM ((BROD)) CYP2A6, Ki: 60 μM ((COH)) CYP2E1, IC₅₀: 25 μM ((CHZ))	CYP3A4, Ki: 10 μM ((TST))	CYP4A, IC₅₀: 15 μM ((LwOH))												≥98.0%
Resorufin methyl ether	CYP1															99.75%
Endoxifen-d₅							Aromatase
CYP11B2-IN-1					CYP11B2, IC₅₀: 2.3 nM CYP11B1, IC₅₀: 142 nM											99.83%
MCH-1 antagonist 1			CYP3A4, IC₅₀: 10 μM
Tabimorelin			CYP3A4													98.11%
Gemfibrozil (Standard)	CYP1A2	CYP2C19 CYP2C8 CYP2C9														99.90%
Bucolome		CYP2														98.93%
Eriodictyol chalcone							Aromatase
1-(Isothiazol-3-yl)ethan-1-one		CYP2E1
4,5-Dimethoxycanthin-6-one	CYP1A2, IC₅₀: 1.7 μM CYP1A2, Ki: 2.6 μM															98.68%
Revexepride			CYP3A4													99.84%
Dibenzothiophene	CYP1															99.88%
Anastrozole-d₁₂							Aromatase
BMS-986339		CYP2C8, IC₅₀: 8 μM CYP2C9, IC₅₀: 13.5 μM
IHMT-PI3Kδ-372		CYP2C9, IC₅₀: 2.7 μM
Fadrozole hydrochloride hemihydrate							Aromatase
Antibacterial agent 132							Aromatase
Anticancer agent 78							Aromatase
Antitumor agent-88	CYP1A1, Ki: 1.4 μM
BNS808	CYP1A2, IC₅₀: 18.0 μM	CYP2C9, IC₅₀: 2.99 μM CYP2C19, IC₅₀: 8.33 μM CYP2D6, IC₅₀: >50 μM
Tetrahydrocurcumin-d₆		CYP2	CYP3
CYP1B1-IN-5	CYP1B1, IC₅₀: 4.7 nM CYP1A1, IC₅₀: 190.7 nM CYP1A2, IC₅₀: 585.7 nM
RO6889678			CYP3A4
ERα degrader 9							Aromatase
Tabimorelin hemifumarate			CYP3A4
CYP17A1/HDAC6-IN-1															CYP17A1, IC₅₀: 0.284 μM
ASN-001															CYP17A1
Monoamine oxidase/Aromatase-IN-1							Aromatase
Exemestane-¹³C₃							Aromatase
CYP11B1-IN-2	CYP1A2, IC₅₀: >10 μM	CYP2C9, IC₅₀: >10 μM CYP2C19, IC₅₀: >10 μM CYP2D6, IC₅₀: >10 μM CYP2E1, IC₅₀: >10 μM	CYP3A4, IC₅₀: >10 μM		CYP11B1, IC₅₀: 9 ± 2 nM (human CYP11B1) CYP11B1, IC₅₀: 25 nM (rat CYP11B1) CYP11B2, IC₅₀: 1121 ± 237 nM
EGFR-IN-137							Aromatase, IC₅₀: 4.01 μM
CYP51/HDAC-IN-1									CYP51
HIV-1 inhibitor-40		CYP2C9, IC₅₀: 5.16 μM CYP2C19, IC₅₀: 4.51 μM
DL-Acetylshikonin	CYP1A2, IC₅₀: 4.0 μM	CYP2A6, IC₅₀: 3.8 μM CYP2B6, IC₅₀: 2.0 μM CYP2C8, IC₅₀: 1.4 μM CYP2C9, IC₅₀: 3.3 μM CYP2C19, IC₅₀: 2.5 μM CYP2D6, IC₅₀: 2.5 μM CYP2E1, IC₅₀: 2.7 μM CYP2J2, IC₅₀: 3.3 μM	CYP3A, IC₅₀: 2.3 μM
CFG920					CYP11B2	CYP17
Phortress free base	CYP1
Vorozole							Aromatase
Antitumor agent-87	CYP1A1, Ki: 0.23 μM
Antiproliferative agent-53-d₃		CYP2C19, IC₅₀: 0.77 μM CYP2C9, IC₅₀: 3.1 μM CYP2D6, IC₅₀: 17.3 μM	CYP3A4, IC₅₀: 14.6 μM
1,2,3,6,7,8-Hexachlorodibenzofuran	CYP1A1
PROTAC ERα Degrader-9							Aromatase, IC₅₀: 4.6 μM
CYP3A4-IN-2			CYP3A4, IC₅₀: 0.055 μM
5,7,2',6'-Tetrahydroxyflavone			CYP3A4, IC₅₀: 7.8 μM
GlcN-6-P Synthase-IN-1			CYP3
SYN20028567							Aromatase
N-Desmethyl diltiazem hydrochloride			CYP3A7
hCYP3A4-IN-1			CYP3A4, IC₅₀: 43.93 nM
Aromatase-IN-3							Aromatase, IC₅₀: 54 nM
JNK-IN-14											CYP2D6, IC₅₀: 26.7 ± 0.5 nM			CYP3A4, IC₅₀: 383.0 ± 1. nM
Licopyranocoumarin			CYP3A4, IC₅₀: 32 μM
7-Ethoxy-4-methylcoumarin	CYP1A1	CYP2B6 CYP2B4														99.44%
CYP3A4-IN-3			CYP3A4, IC₅₀: 0.075 μM
CYP4Z1-IN-1		CYP2D6, IC₅₀: >10 000 nM CYP2C9, IC₅₀: >10 000 nM	CYP3A4, IC₅₀: >10 000 nM	CYP4Z1, IC₅₀: 41.8 ± 1.4 nM CYP4F11, IC₅₀: 291.3 ± 46 nM CYP4F12, IC₅₀: 1598.3 ± 5 nM
CYP17A1-IN-1						CYP17, IC₅₀: 26 nM
17(S)-HETE	CYP1B1
Melperone hydrochloride											CYP2D6
BI 653048 phosphate	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM
Ginsenoside Rd (Standard)	CYP1A2	CYP2C9 CYP2D6	CYP3A4
CYP11B2-IN-3					CYP11B2, IC₅₀: 12.92 nM
Kushenol K			CYP3A4, Ki: 1.35 μM
Androsta-1,4,6-triene-3,17-dione							Aromatase
CYP51/PD-L1-IN-4									CYP51, IC₅₀: 0.17 ± 0.0 μM
Exemestane-d₂							Aromatase
Diosmetin (Standard)	CYP1
Fenofibrate-d₆		CYP2	CYP3													99.70%
Ginsenoside C-K (Standard)		CYP2A6 CYP2C9
Galangin (Standard)	CYP1
FGFRs-IN-1										CYP1A2, IC₅₀: 26.33 μM	CYP2D6, IC₅₀: 9.27 μM		CYP2C19, IC₅₀: 11.46 μM
7-Hydroxyflavanone							Aromatase									99.59%
Oxolamine		CYP2B1 CYP2B2
TRPV1 antagonist 10	CYP1A2, IC₅₀: 28.31 μM	CYP2C9, IC₅₀: 42.85 μM CYP2C19, IC₅₀: 9.23 μM CYP2D6, IC₅₀: >100 μM	CYP3A4M, IC₅₀: 8.73 μM
Oxolamine hydrochloride		CYP2B1 CYP2B2
BChE-IN-33		CYP2C19 CYP2C9 CYP2D6
FGFR-IN-10		CYP2C9, IC₅₀: 3.33 μM CYP2C19, IC₅₀: 18.75 μM CYP2D6, IC₅₀: 4.34 μM	CYP3A4, IC₅₀: 0.69 μM
CYP1B1-IN-3	CYP1B1, IC₅₀: 6.6 nM CYP1A1, IC₅₀: 347.3 nM CYP1A2, IC₅₀: >10000 nM
Nav1.7-IN-8		CYP2C9, IC₅₀: 0.17 μM	CYP3A4, IC₅₀: 0.077 μM
Aromatase-IN-2							Aromatase									99.83%
PROTAC CYP1B1 degrader-2	CYP1B1, DC₅₀: 1 nM
CYP3A4-IN-1			CYP3A4, IC₅₀: 0.085 μM
P-gp inhibitor 23														CYP3A4
CYP1B1-IN-2	CYP1B1, IC₅₀: 0.52 nM CYP1A1, IC₅₀: 16.7 nM CYP1A2, IC₅₀: 94.2 nM
hCYP1B1-IN-2	CYP1B1, IC₅₀: 0.040 nM CYP1A1, IC₅₀: 0.38 nM
Methysticin	CYP1A1
Isolimonexic acid							Aromatase
Sorafenib N-oxide														CYP3A4, Ki: 15 μM
10-Hydroxywarfarin												CYP2C9, IC₅₀: 1.6 μM
Thujopsene		CYP2B6, IC₅₀: 1.3 μM CYP2C19, IC₅₀: 13.6 μM CYP2C8, IC₅₀: 29.8 μM CYP2C9, IC₅₀: 44.9 μM	CYP3A4, IC₅₀: 12.6 μM
CYP11B2-IN-2					CYP11B2, IC₅₀: 0.3 nM CYP11B1, IC₅₀: 3.8 nM
Sudan IV-d₆	CYP1A1
Cloperidone												CYP2C9, IC₅₀: 17.7 μM
CYP51/Hsp90-IN-1									CYP51
Sudan IV (Standard)	CYP1A1
CYP4Z1-IN-2				CYP4Z1, Ki: 2.2 μM
Melperone-d₄ hydrochloride											CYP2D6					99.84%
Exemestane-d₃							Aromatase
Melperone (Standard)											CYP2D6
CYP3A4-IN-4			CYP3A4
ML252 hydrochloride	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM
ODM-204						CYP17
Oxiconazole			CYP3A4
Org30958							Aromatase

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